Between and , acinetobacter species were the only .. forms provided by the authors are available with the full text of this article at Go to. Multidrug-resistant Acinetobacter baumannii (MDR-Ab) causes wound and bloodstream infections as well as ventilator-associated pneumonia. of human and animal origin in multiple countries (NEJM Journal Watch Acinetobacter spp., and Pseudomonas aeruginosa from inpatients.

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Epidemiology and outcomes of health-care-associated pneumonia: Furthermore, it was shown to be inferior to imipenem—cilastatin for the treatment of ventilator-associated pneumonia in a randomized, double-blind trial. acinetobactsr

Plus one of the following regimens: Although each sampling method has its limitations, the most important point is to obtain the sample in a timely manner. One of the following regimens: Such patients are more likely to have a coexisting illness and to receive inactive empirical antibiotic therapy and are at greater risk for death than patients who have true community-acquired pneumonia. As has been described for the nonfermenting gram-negative organisms, K.

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Hospital-Acquired Infections Due to Gram-Negative Bacteria

The most recent challenge has been the spread of carbapenemase-producing Enterobacteriaceae. Organisms inherently resistant to polymyxins include serratia, proteus, Stenotrophomonas maltophiliaBurkholderia cepaciaand flavobacterium. Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis.


Clinical experience with treating these multidrug-resistant bacteria remains limited, however. Hospital-acquired infections are most commonly associated with invasive medical njem or surgical procedures. Hospital-acquired infections are nem major challenge to patient safety.

Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Catheter-associated urinary tract infection is rarely symptomatic: In vitro activity of tigecycline against a range of troublesome gram-negative organisms, including ESBL-producing and carbapenemase-producing Enterobacteriaceae, acinetobacter species, and Stenotrophomonas maltophiliahas been reported P. We thank Howard Gold and David Paterson for their critical review of an earlier version of the manuscript.

Gram-negative organisms predominate in hospital-acquired urinary tract infections, almost all of which are associated with urethral catheterization.

Until further data are available, we do not recommend the use of antibiotic-impregnated or silver-coated urinary catheters. Lower respiratory tract and bloodstream infections are the most lethal; however, urinary tract infections are the most common.

The diagnosis of ventilator-associated pneumonia remains challenging, with no easily obtained reference standard.

Hospital-Acquired Infections Due to Gram-Negative Bacteria

Bad bugs, no drugs: Wyeth to file for FDA approval of Tygacil for the treatment of patients with community-acquired pneumonia. Tigecycline, a minocycline derivative with a broader spectrum of activity, is approved for the treatment of complicated skin, soft-tissue, and intraabdominal infections.


Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Comparison of 8 versus 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A compendium acinetobaacter strategies to prevent healthcare-associated infections in acute care hospitals.

With a hospital stay of 5 days or longer, as compared with a shorter stay, the patient is at greater risk for infection with more resistant pathogens, and empirical treatment with broad-spectrum antimicrobial agents should be prescribed see discussion of treatment below.

Adherence to evidence-based interventions has proved highly successful Table 335 and hospitals worldwide should be adopting such cost-effective, preventive measures. Pneumonia Hospital-acquired pneumonia is the most common life-threatening hospital-acquired infection, and the majority of cases are associated with mechanical ventilation. Overview of nosocomial infections caused by gram-negative bacilli. Diagnostic criteria Presence of a new or progressive infiltrate on chest radiography and two of the following three clinical features: These strategies are particularly useful for infections caused by multidrug-resistant organisms Table 5.